Phyllanthus muellerianus(Euphorbiaceae) Restores Ovarian Functions in Letrozole-Induced Polycystic Ovarian Syndrome in Rats
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چکیده
منابع مشابه
P-199: Comparison of Clomiphene Citrate and Letrozole Effect on Folliculogenesis in Polycystic Ovarian Syndrome Patients
Background: Polycystic ovarian syndrome (PCOS) which is the most common form of anovulatory infertility affects 5-10% women of reproductive age. Clomiphene Citrate (C.C) is the first line treatment in infertile women entering intrauterine insemination (IUI) cycle. For C.C resistant patients the second approach is aromatase inhibitors such as Letrozole. The aim of this study is to compare the ef...
متن کاملP-207: Pharmacogenetic Study of CYP19A1 (Aromatase) in Ovarian Induction in Iranian Polycystic Ovarian Syndrome Patients
Background: Hyper-androgenemia is one of the main clinical features of polycystic ovarian syndrome (PCOS). Letrozol is an aromatase inhibitor drug, which is co-administered with gonadotropins in most cases of PCOS, to improve ovulation. Aromatase has a critical role in catalyzing the conversion of androgens to estrogens and is responsible for keeping the homeostatic balance between them. Hence ...
متن کاملIn Vitro Oocyte Maturation in Polycystic Ovarian Syndrome Patients
Prevalence of Polycystic Ovarian Syndrome(PCOS) in Iran is more than 6%. Therefore we encounter with many PCOS patients. In Vitro Maturation (IVM) of oocytes as an attractive method in ART is considered. Studies show that changes in culture conditions should be administered to make IVM protocol more successful .For this purpose in this study we have set up the beneficial cultures for IVM proced...
متن کاملProtective effects of GABA against metabolic and reproductive disturbances in letrozole induced polycystic ovarian syndrome in rats
BACKGROUND PCOs is a heterogeneous disorder with anovulation/oligo ovulation usually taken as oligo menorrhoea or amenorrhoea, hyperandrogenemia, hirsutism, acne, androgen alopecia and polycystic ovaries as the key diagnostic feathers. The study was undertaken to investigate the possible protective and ameliorating effects of GABA in Letrozole induced PCOS model in rats by targeting insulin res...
متن کاملUnilateral sectioning of the superior ovarian nerve of rats with polycystic ovarian syndrome restores ovulation in the innervated ovary
The present study tested the hypothesis that if polycystic ovary syndrome (PCOS) results from activating the noradrenergic outflow to the ovary, unilaterally sectioning the superior ovarian nerve (SON) will result in ovulation by the denervated ovary, and the restoration of progesterone (P4), testosterone (T) and estradiol (E2) normal serum level. A single 2 mg dose of estradiol valerate (EV) t...
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ژورنال
عنوان ژورنال: Evidence-Based Complementary and Alternative Medicine
سال: 2019
ISSN: 1741-427X,1741-4288
DOI: 10.1155/2019/2965821